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Neuropathic pain: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then improve the dose
in response to response in steps of 300 mg every day to maximum
1800 mg every day in three divided doses. Upkeep dose is 900 mg each day (body
weight 26-36 Kg) or 1.2 gm day by day (physique weight 37-50 Kg).
Partial seizure/epilepsy: 300 mg on day-1, then 300 mg twice
on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg
daily to most 2400 mg daily in three divided doses.
For 3-12 years: 10 to 15 mg/kg, Incase of titration 25-35
mg/kg every day in 3 divided doses. Nortriptyline should not
be given with adrenaline, ephedrine, isoprenaline,
noradrenaline, phenylephrine, phenylpropanolamine,
medicine that are metabolized by CYP4502D6, MAOIs, guanethidine, debrisoquine, bethanidine, clonidine and reserpine and
many others. Barbiturates might improve the speed of metabolism of nortriptyline.